Protease-activated alpha-2-macroglobulins bind to pro-inflammatory cytokines including TNF-alpha and IL-1 beta, facilitating their rapid clearance through the liver, as well as to anti-inflammatory cytokines such as TGF-beta, assisting in their stimulation of tissue repair.^[21-23] These activated macroglobulins have also been found to help control the presence of other pro-inflammatory mediators, especially kinins and prostaglandins, in damaged tissue which may result in less pain, reduced edema and faster recovery.^{[7, 24-28]} The modulating effect of supplemental proteases like pHysioProtease® on inflammation is further supported by studies showing activated alpha-2-macroglobulins can slow the migration of neutrophils to sites of tissue damage or deterioration as well as enhance the activity of macrophages and natural killer cells.^[29-33]*